Absorption of m-xylene vapours through the respiratory tract and excretion of m-methylhippuric acid in urine.
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Absorption of m-xylene vapours through the respiratory tract and excretion of m-methylhippuric acid in urine.
Absorption of m-xylene and excretion of m-methylhippuric acid were investigated under controlled conditions in ten volunteers aged 17-33 years. They were exposed to m-xylene vapours at concentrations of 100, 300, and 600 mg/m3. It was found that m-xylene vapour retained in the lungs tended to decrease at the end of the exposure. An exposure test was devised, based upon the results obtained duri...
متن کاملUrinary excretion of hippuric acid and m- or p-methylhippuric acid in the urine of persons exposed to vapours of toluene and m- or p-xylene as a test of exposure.
Ogata, M., Tomokuni, K., and Takatsuka, Y. (1970). Brit. J. industr. Med., 27,43-50. Urinary excretion of hippuric acid and mor p-methylhippuric acid in the urine of persons exposed to vapours of toluene and mor p-xylene as a test of exposure. Twenty-three male volunteers were exposed in groups of four or five to toluene and mand p-xylene vapour for periods of 3 hours or of 7 hours with one bre...
متن کاملThin-layer chromatography of hippuric and m-methylhippuric acid in urine after mixed exposure to toluene and xylene.
The separation of hippuric and m-methylhippuric acid as toluene and m-xylene metabolites present in urine of people exposed simultaneously to toluene and xylene is described. Chloroform was used for hippuric and m-methylhippuric acid extraction. Satisfactory separation of these metabolites was obtained on TLC plates covered with silica gels and developed in chloroform acetic acid-water (4:1:1);...
متن کاملAbsorption of cumene through the respiratory tract and excretion of dimethylphenylcarbinol in urine.
Experiments on the absorption of cumene and the excretion of dimethylphenylcarbinol were made on 10 healthy volunteers, five men and five women aged between 20 and 35 years. They were exposed to cumene vapours 240, 480, 720 mg/m3 under controlled conditions. It was found that the average retention of cumene vapours was about 50% which tended to diminish at the end of each exposure. Based on the...
متن کاملAcute Inhaled Xylene Poisoning Confirmed by Methylhippuric Acid Urine Test
Xylene is a commonly used toxic volatile organic solvent. Diagnosis of acute xylene poisoning is limited by the lack of a readily available analytic assay. Methylhippuric acid, a metabolite of xylene excreted in the urine, is used for biomonitoring occupational exposures to xylene. We report two cases of acute occupational poisoning from xylene inhalation suggested by determination of high urin...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1978
ISSN: 1351-0711
DOI: 10.1136/oem.35.1.50